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KMID : 0370220090530030151
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Yakhak Hoeji
2009 Volume.53 No. 3 p.151 ~ p.155
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Effect of Meteorin on the Regulation of TSP-1 via Signalings in Astrocytes
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Park Soo-Youn
Park Jeong-Ae
Ko Keum-Jae
Lee Hye-Shin
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Abstract
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Meteorin in astrocytes has antiangiogenic activities via thrombospondin-1 (TSP-1), however, the regulatory mechanism has been unclear. Here we report that Meteorin upregulates TSP transcriptionally through luciferase reporter assays in astrocytes. Moreover, Meteorin activates and ERK1/2 in astrocytes. Inhibition of and ERK1/2 activities attenuated expression of TSP-1 by Meteorin in astrocytes. We, therefore, demonstrate that Meteorin activates signaling and, in turn, increases TSP-1 expression in astrocytes to inhibit angiogenesis in the brain.
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KEYWORD
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astrocyte, meteorin, TSP-1, , brain, thrombospondin-1
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